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Submit ReviewBombinakinin M
Description: Potent bradykinin agonist
Alternative Names: Maximakinin
Biological Activity for Bombinakinin M
Bombinakinin M is a potent bradykinin receptor agonist. Highly selective for mammalian arterial smooth muscle bradykinin receptors, displaying ~ 50-fold greater potency than bradykinin. Elicits dose-dependent contractile effects in smooth muscle of guinea pig ileum (EC50 = 4.0 nM).
Technical Data for Bombinakinin M
| M. Wt | 2179.55 |
| Formula | C100H159N31O24 |
| Sequence | DLPKINRKGPRPPGFSPFR |
| Storage | Desiccate at -20°C |
| CAS Number | 509151-65-9 |
| PubChem ID | 90473828 |
| InChI Key | ZEEWOWMYALYVCG-UOGIEMGNSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bombinakinin M
References for Bombinakinin M
References are publications that support the biological activity of the product.
Lai et al (2001) A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identicals copies of the final product. Biochem.Biophys.Res.Comm. 286 259
O'Rourke et al (2004) The smooth muscle pharmacology of maximakinin, a receptor-selective, bradykinin-related nonadecapeptide from the venom of the Chinese toad, Bombina maxima. Regul.Peptides 121 65
Lee et al (2005) Cloning of bradykinin precursor cDNAs from skin of Bombina maxima reveals novel bombinakinin M antagonists and a bradykinin potential peptide. Regul.Peptides 127 207
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Keywords: Bombinakinin M, Bombinakinin M supplier, Potent, bradykinin, receptor, agonists, B1, B2, Receptors, Bradykinin, BombinakininM, Maximakinin, 2371, Tocris Bioscience
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