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Submit ReviewABT 702 hydrochloride
Description: Adenosine kinase inhibitor; orally active
Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ABT 702 hydrochloride
ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.
Technical Data for ABT 702 hydrochloride
| M. Wt | 499.79 |
| Formula | C22H19N6OBr.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2624336-92-9 |
| PubChem ID | 16760265 |
| InChI Key | KXHYOZCVILMBFV-UHFFFAOYSA-N |
| Smiles | NC1=C2C(N=C(C3=CN=C(N4CCOCC4)C=C3)C=C2C5=CC(Br)=CC=C5)=NC=N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ABT 702 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.66 | 100 |
Preparing Stock Solutions for ABT 702 hydrochloride
The following data is based on the product molecular weight 499.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10 mL | 20.01 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for ABT 702 hydrochloride
References for ABT 702 hydrochloride
References are publications that support the biological activity of the product.
Jarvis et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther. 295 1156 PMID: 11082453
Kowaluk et al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 295 1165 PMID: 11082454
Lee et al (2001) Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 44 2133 PMID: 11405650
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Keywords: ABT 702 hydrochloride, ABT 702 hydrochloride supplier, adenosines, kinases, inhibitors, inhibits, orally, active, ADK, Receptors, ABT702, hydrochloride, Adenosine, Kinase, Other, 2372, Tocris Bioscience
3 Citations for ABT 702 hydrochloride
Citations are publications that use Tocris products. Selected citations for ABT 702 hydrochloride include:
Fassett et al (2011) Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol 300 H1722 PMID: 21335462
Hobson et al (2012) Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats. Neuropharmacology 63 1172 PMID: 22749927
Ahwazi et al (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochem J 478 2977 PMID: 34259310
Do you know of a great paper that uses ABT 702 hydrochloride from Tocris? Please let us know.
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