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Submit Reviewtrans-4-Hydroxycrotonic acid
Description: GHB receptor ligand
Chemical Name: trans-4-Hydroxy-2-butenoic acid
Purity: ≥99% (HPLC)
Biological Activity for trans-4-Hydroxycrotonic acid
Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. May be an endogenous ligand.
Technical Data for trans-4-Hydroxycrotonic acid
| M. Wt | 102.09 |
| Formula | C4H6O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 24587-49-3 |
| PubChem ID | 6155526 |
| InChI Key | RMQJECWPWQIIPW-OWOJBTEDSA-N |
| Smiles | OC\C=C\C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for trans-4-Hydroxycrotonic acid
References for trans-4-Hydroxycrotonic acid
References are publications that support the biological activity of the product.
Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893 PMID: 3361576
Hechler et al (1993) Gamma hydroxybutyrate ligands posses antiDArgic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406 PMID: 8095552
Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401 PMID: 4015683
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Keywords: trans-4-Hydroxycrotonic acid, trans-4-Hydroxycrotonic acid supplier, GHB, receptor, ligand, GABAB, Receptors, GABAA, GABAC, Miscellaneous, GABA, 0538, Tocris Bioscience
Citations for trans-4-Hydroxycrotonic acid
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Currently there are no citations for trans-4-Hydroxycrotonic acid.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.