Ro 90-7501

Pricing Availability   Qty
Description: Inhibitor of Aβ42 fibril formation
Chemical Name: 2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for Ro 90-7501

Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).

Compound Libraries for Ro 90-7501

Ro 90-7501 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 90-7501

M. Wt 340.39
Formula C20H16N6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 293762-45-5
PubChem ID 824226
InChI Key PAGZCEHLFCJSPV-UHFFFAOYSA-N
Smiles NC1=CC=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(N)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 90-7501

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 3.4 10
DMSO 34.04 100

Preparing Stock Solutions for Ro 90-7501

The following data is based on the product molecular weight 340.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for Ro 90-7501

Certificate of Analysis / Product Datasheet
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References for Ro 90-7501

References are publications that support the biological activity of the product.

Bohrmann et al (2000) Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 130 232 PMID: 10940228


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Keywords: Ro 90-7501, Ro 90-7501 supplier, inhibitors, inhibits, Aβ4, β42, beta42, fibril, formation, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, Ro90-7501, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, 2408, Tocris Bioscience

Citations for Ro 90-7501

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Literature in this Area

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