Home / Pharmacology / Enzymes / Proteases / Calpains / Calpain Inhibitors / PD 150606

PD 150606

Cat. No. 1269 6 Citations Submit a Review Datasheet / COA / SDS
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Description: Cell permeable calpain inhibitor
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PD 150606

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

Technical Data for PD 150606

M. Wt 306.12
Formula C9H7IO2S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 179528-45-1
PubChem ID 9839500
InChI Key DJCVSFWGKYHMKH-YVMONPNESA-N
Smiles IC1=CC=C(/C=C(C(O)=O)\S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 150606

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.61 100
ethanol 15.31 50

Preparing Stock Solutions for PD 150606

The following data is based on the product molecular weight 306.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.67 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets for PD 150606

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for PD 150606

References are publications that support the biological activity of the product.

Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777

Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879

Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991

If you know of a relevant reference for PD 150606, please let us know.

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Keywords: PD 150606, PD 150606 supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Calpains, 1269, Tocris Bioscience

6 Citations for PD 150606

Citations are publications that use Tocris products. Selected citations for PD 150606 include:

Chang et al (2017) Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife 6 PMID: 29271742

Pradhan et al (2017) The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol 429 192 PMID: 27986570

Getz et al (2016) Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep 6 31779 PMID: 27538741

Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817

Do you know of a great paper that uses PD 150606 from Tocris? Please let us know.

Reviews for PD 150606

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets

Pathways for PD 150606

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.