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Submit ReviewCPT 11
Description: DNA topoisomerase I inhibitor; antitumor
Alternative Names: Irinotecan,Camptothecin 11
Chemical Name: (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CPT 11
CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).
Compound Libraries for CPT 11
CPT 11 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for CPT 11
| M. Wt | 623.14 |
| Formula | C33H38N4O6.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 100286-90-6 |
| PubChem ID | 74990 |
| InChI Key | GURKHSYORGJETM-WAQYZQTGSA-N |
| Smiles | CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CPT 11
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.12 | 5 with gentle warming | |
| DMSO | 62.31 | 100 |
Preparing Stock Solutions for CPT 11
The following data is based on the product molecular weight 623.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.6 mL | 8.02 mL | 16.05 mL |
| 5 mM | 0.32 mL | 1.6 mL | 3.21 mL |
| 10 mM | 0.16 mL | 0.8 mL | 1.6 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
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Product Datasheets for CPT 11
References for CPT 11
References are publications that support the biological activity of the product.
Kawato et al (1993) Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 45 444 PMID: 8099964
Vassal et al (1996) Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 74 537 PMID: 8761367
Morton et al (2005) Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 56 629 PMID: 15918039
If you know of a relevant reference for CPT 11, please let us know.
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Keywords: CPT 11, CPT 11 supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, CPT11, Camptothecin11, chemotherapeutics, Irinotecan, Camptothecin, 11, Topoisomerase, 2688, Tocris Bioscience
1 Citation for CPT 11
Citations are publications that use Tocris products. Selected citations for CPT 11 include:
Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727
Do you know of a great paper that uses CPT 11 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.