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Submit ReviewPentylenetetrazole
Description: CNS stimulant
Alternative Names: PTZ
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity: ≥99% (HPLC)
Biological Activity for Pentylenetetrazole
Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
Technical Data for Pentylenetetrazole
| M. Wt | 138.17 |
| Formula | C6H10N4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 54-95-5 |
| PubChem ID | 5917 |
| InChI Key | CWRVKFFCRWGWCS-UHFFFAOYSA-N |
| Smiles | C1CCN2N=NN=C2CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pentylenetetrazole
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.81 | 100 | |
| DMSO | 13.81 | 100 |
Preparing Stock Solutions for Pentylenetetrazole
The following data is based on the product molecular weight 138.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.24 mL | 36.19 mL | 72.37 mL |
| 5 mM | 1.45 mL | 7.24 mL | 14.47 mL |
| 10 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 50 mM | 0.14 mL | 0.72 mL | 1.45 mL |
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Product Datasheets for Pentylenetetrazole
References for Pentylenetetrazole
References are publications that support the biological activity of the product.
Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692
Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561
Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478
If you know of a relevant reference for Pentylenetetrazole, please let us know.
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Keywords: Pentylenetetrazole, Pentylenetetrazole supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, PTZ, Miscellaneous, GABA, 2687, Tocris Bioscience
1 Citation for Pentylenetetrazole
Citations are publications that use Tocris products. Selected citations for Pentylenetetrazole include:
Karim et al (2012) 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol 165 880 PMID: 21797842
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Reviews for Pentylenetetrazole
Average Rating: 5 (Based on 1 Review.)
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Use of pentylenetetrazole as GABA-A receptor antagonist.
By
Anonymous on 08/31/2019
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum
Pentylenetetrazole was used for pharmacological isolation of glycine receptors response as a GABA-A receptor antagonist with low or no affinity to glycine receptor (GlyR). Clear GlyR single-channel openings with characteristic conductance states were obtained. Figure: recording of GlyR single-channel openings with 1 mM pentylenetetrazole in perfusion solution.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.