BIBU 1361 dihydrochloride

Discontinued Product

2417 has been discontinued.

View all EGFR products.
Description: Selective inhibitor of EGFR-kinase
Chemical Name: N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for BIBU 1361 dihydrochloride

BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

Technical Data for BIBU 1361 dihydrochloride

M. Wt 516.87
Formula C22H27ClFN7.2HCl
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 1643609-75-9
PubChem ID 46861539
InChI Key ZNNWCQCQUKAMGL-UHFFFAOYSA-N
Smiles Cl.Cl.CCN(CC)CC1CCN(CC1)C1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BIBU 1361 dihydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for BIBU 1361 dihydrochloride

References are publications that support the biological activity of the product.

Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID: 15199094

View Related Products by Product Action

View all EGFR Inhibitors

Keywords: BIBU 1361 dihydrochloride, BIBU 1361 dihydrochloride supplier, Selective, inhibitors, inhibits, EGFR-kinases, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, BIBU1361, dihydrochloride, EGFR, 2417, Tocris Bioscience

Citations for BIBU 1361 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for BIBU 1361 dihydrochloride.

Reviews for BIBU 1361 dihydrochloride

There are currently no reviews for this product. Be the first to review BIBU 1361 dihydrochloride and earn rewards!

Have you used BIBU 1361 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.