Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review[Pyr1]-Apelin-13
Description: Potent peptide apelin agonist
Alternative Names: [pGlu1]-Apelin-13
Purity: ≥95% (HPLC)
Biological Activity for [Pyr1]-Apelin-13
[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
Technical Data for [Pyr1]-Apelin-13
| M. Wt | 1533.81 |
| Formula | C69H108N22O16S |
| Sequence |
XRPRLSHKGPMPF (Modifications: X = Glp) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 217082-60-5 |
| PubChem ID | 25085173 |
| InChI Key | GGMAXEWLXWJGSF-PEWBXTNBSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [Pyr1]-Apelin-13
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for [Pyr1]-Apelin-13
References for [Pyr1]-Apelin-13
References are publications that support the biological activity of the product.
Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876
Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471
Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343
If you know of a relevant reference for [Pyr1]-Apelin-13, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: [Pyr1]-Apelin-13, [Pyr1]-Apelin-13 supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, [pGlu1]-Apelin-13, 2420, Tocris Bioscience
2 Citations for [Pyr1]-Apelin-13
Citations are publications that use Tocris products. Selected citations for [Pyr1]-Apelin-13 include:
Hall et al (2017) Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett 386 179 PMID: 27894959
Li (2018) Apelin modulates murine gastric vagal afferent mechanosensitivity. Physiol Behav 194 466 PMID: 29964068
Do you know of a great paper that uses [Pyr1]-Apelin-13 from Tocris? Please let us know.
Reviews for [Pyr1]-Apelin-13
There are currently no reviews for this product. Be the first to review [Pyr1]-Apelin-13 and earn rewards!
Have you used [Pyr1]-Apelin-13?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image