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Submit Review2-Hydroxysaclofen
Description: Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Biological Activity for 2-Hydroxysaclofen
2-Hydroxysaclofen is a selective antagonist at GABAB receptors.
Technical Data for 2-Hydroxysaclofen
| M. Wt | 265.71 |
| Formula | C9H12ClNO4S |
| Storage | Store at RT |
| CAS Number | 117354-64-0 |
| PubChem ID | 1564 |
| InChI Key | WBSMZVIMANOCNX-UHFFFAOYSA-N |
| Smiles | NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-Hydroxysaclofen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5 | ||
| 1eq. NaOH | 100 |
Preparing Stock Solutions for 2-Hydroxysaclofen
The following data is based on the product molecular weight 265.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.76 mL | 18.82 mL | 37.64 mL |
| 5 mM | 0.75 mL | 3.76 mL | 7.53 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets for 2-Hydroxysaclofen
References for 2-Hydroxysaclofen
References are publications that support the biological activity of the product.
Curtis et al (1988) Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 92 97 PMID: 2847093
Kerr et al (1988) 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 92 92 PMID: 2847092
If you know of a relevant reference for 2-Hydroxysaclofen, please let us know.
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Keywords: 2-Hydroxysaclofen, 2-Hydroxysaclofen supplier, Selective, GABAB, antagonists, Receptors, 0245, Tocris Bioscience
2 Citations for 2-Hydroxysaclofen
Citations are publications that use Tocris products. Selected citations for 2-Hydroxysaclofen include:
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature 101 2151 PMID: 14766975
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585
Do you know of a great paper that uses 2-Hydroxysaclofen from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.