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Submit ReviewICI 174,864
Description: δ selective peptide antagonist
Purity: ≥95% (HPLC)
Biological Activity for ICI 174,864
ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ICI 174,864
| M. Wt | 691.87 |
| Formula | C38H53N5O7 |
| Sequence |
YXXFL (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 89352-67-0 |
| PubChem ID | 44149909 |
| InChI Key | XUWLAGNFLUARAN-CHQNGUEUSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICI 174,864
| Solubility | Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water |
Product Datasheets for ICI 174,864
References for ICI 174,864
References are publications that support the biological activity of the product.
Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170
Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195
Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731
Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739
If you know of a relevant reference for ICI 174,864, please let us know.
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Keywords: ICI 174,864, ICI 174,864 supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, 0820, Tocris Bioscience
5 Citations for ICI 174,864
Citations are publications that use Tocris products. Selected citations for ICI 174,864 include:
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462
Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632
Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753
Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730
Do you know of a great paper that uses ICI 174,864 from Tocris? Please let us know.
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