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Submit ReviewICI 192,605
Description: Potent thromboxane A2/TP receptor antagonist
Chemical Name: 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid
Purity: ≥98% (HPLC)
Biological Activity for ICI 192,605
Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ICI 192,605
| M. Wt | 402.87 |
| Formula | C22H23ClO5 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 117621-64-4 |
| PubChem ID | 6604763 |
| InChI Key | WHUIENZXNGAHQI-GKZDNZBASA-N |
| Smiles | OC(=O)CC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C1=C(Cl)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ICI 192,605
References for ICI 192,605
References are publications that support the biological activity of the product.
Arakawa et al (1993) Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor. Br.J.Pharmacol. 110 127 PMID: 8220872
Brewster et al (1988) The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605. Prostaglandins 36 173 PMID: 2973084
Cao et al (2004) Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur.J.Pharmacol. 485 317 PMID: 14757156
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Keywords: ICI 192,605, ICI 192,605 supplier, Potent, thromboxane, A2, TXA2, TP, receptor, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI192605, AstraZeneca, Receptors, 0837, Tocris Bioscience
1 Citation for ICI 192,605
Citations are publications that use Tocris products. Selected citations for ICI 192,605 include:
Daray et al (2003) Pharmacological characterization of prostanoid receptors mediating vasoconstriction in human umbilical vein. Naunyn Schmiedebergs Arch Pharmacol 139 1409 PMID: 12922927
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