Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewImetit dihydrobromide
Description: Standard H3 and H4 agonist (H3 > H4)
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Biological Activity for Imetit dihydrobromide
Imetit dihydrobromide is an an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Technical Data for Imetit dihydrobromide
| M. Wt | 332.06 |
| Formula | C6H10N4S.2HBr |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 32385-58-3 |
| PubChem ID | 11957573 |
| InChI Key | DOBOYMKCRRLTRF-UHFFFAOYSA-N |
| Smiles | Br.Br.NC(=N)SCCC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Imetit dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.21 | 100 |
Preparing Stock Solutions for Imetit dihydrobromide
The following data is based on the product molecular weight 332.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.06 mL | 30.12 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Imetit dihydrobromide
References for Imetit dihydrobromide
References are publications that support the biological activity of the product.
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276
Garbarg et al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J.Pharmacol.Exp.Ther. 263 304 PMID: 1383495
Ling et al (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161 PMID: 15131002
If you know of a relevant reference for Imetit dihydrobromide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Imetit dihydrobromide, Imetit dihydrobromide supplier, H3, H4, agonists, Receptors, Histamine, histaminergic, 0729, Tocris Bioscience
3 Citations for Imetit dihydrobromide
Citations are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:
Hashikawa-Hobara et al (2012) Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. Evid Based Complement Alternat Med 340 185 PMID: 22011436
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
Yoshimoto et al (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A 103 13866 PMID: 16954192
Do you know of a great paper that uses Imetit dihydrobromide from Tocris? Please let us know.
Reviews for Imetit dihydrobromide
There are currently no reviews for this product. Be the first to review Imetit dihydrobromide and earn rewards!
Have you used Imetit dihydrobromide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.