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Submit ReviewL-NIO dihydrochloride
Description: NOS inhibitor
Chemical Name: N5-(1-Iminoethyl)-L-ornithine dihydrochloride
Biological Activity for L-NIO dihydrochloride
L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.
Technical Data for L-NIO dihydrochloride
| M. Wt | 246.13 |
| Formula | C7H15N3O2.2HCl |
| Storage | Desiccate at -20°C |
| CAS Number | 159190-44-0 |
| PubChem ID | 2733507 |
| InChI Key | RYCMAAFECCXGHI-ILKKLZGPSA-N |
| Smiles | N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-NIO dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.61 | 100 |
Preparing Stock Solutions for L-NIO dihydrochloride
The following data is based on the product molecular weight 246.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.06 mL | 20.31 mL | 40.63 mL |
| 5 mM | 0.81 mL | 4.06 mL | 8.13 mL |
| 10 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.81 mL |
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Product Datasheets for L-NIO dihydrochloride
References for L-NIO dihydrochloride
References are publications that support the biological activity of the product.
Moncada et al (1997) XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 49 137 PMID: 9228663
Mulligan et al (1992) Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 107 1159 PMID: 1281719
Rees et al (1990) Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 101 746 PMID: 1706208
If you know of a relevant reference for L-NIO dihydrochloride, please let us know.
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Keywords: L-NIO dihydrochloride, L-NIO dihydrochloride supplier, Potent, eNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Endothelial, Synthase, NO, Synthases, iNOS, nNOS, 0546, Tocris Bioscience
8 Citations for L-NIO dihydrochloride
Citations are publications that use Tocris products. Selected citations for L-NIO dihydrochloride include:
Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451
Wu et al (2013) Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). PLoS One 8 e55739 PMID: 23405205
Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Endocrinology 10 e0140762 PMID: 26485682
Bergeron et al (2015) Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. PLoS Negl Trop Dis 156 638 PMID: 25456068
Bender and Abdel-Rahman (2010) Differential central NOS-NO signaling underlies clon. exacerbation of ethanol-evoked behavioral impairment. Alcohol Clin Exp Res 34 555 PMID: 20028349
Penumarti and Abdel-Rahman (2014) Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats. J Pharmacol Exp Ther 351 44 PMID: 25100751
Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924
Chang et al (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol 136 43313 PMID: 11976262
Do you know of a great paper that uses L-NIO dihydrochloride from Tocris? Please let us know.
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