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Submit ReviewImmepip dihydrobromide
Description: Standard H3 agonist. Also H4 agonist
Chemical Name: 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
Biological Activity for Immepip dihydrobromide
Immepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.
Technical Data for Immepip dihydrobromide
| M. Wt | 327.06 |
| Formula | C9H15N3.2HBr |
| Storage | Desiccate at RT |
| CAS Number | 164391-47-3 |
| PubChem ID | 22315065 |
| InChI Key | YGNJPNRDGXJQJX-UHFFFAOYSA-N |
| Smiles | Br.Br.C(C1CCNCC1)C1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Immepip dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.71 | 100 |
Preparing Stock Solutions for Immepip dihydrobromide
The following data is based on the product molecular weight 327.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.06 mL | 15.29 mL | 30.58 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.12 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.06 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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Product Datasheets for Immepip dihydrobromide
References for Immepip dihydrobromide
References are publications that support the biological activity of the product.
Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569 PMID: 7675114
Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434
Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332 PMID: 8308858
If you know of a relevant reference for Immepip dihydrobromide, please let us know.
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Keywords: Immepip dihydrobromide, Immepip dihydrobromide supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, 0932, Tocris Bioscience
1 Citation for Immepip dihydrobromide
Citations are publications that use Tocris products. Selected citations for Immepip dihydrobromide include:
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423
Do you know of a great paper that uses Immepip dihydrobromide from Tocris? Please let us know.
Reviews for Immepip dihydrobromide
Average Rating: 5 (Based on 1 Review.)
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Study of H4 receptor in the DGR neurons.
By
Anonymous on 12/24/2019
Species: Human
To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.
We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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