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Description: Potent σ antagonist
Chemical Name: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine
Purity: ≥98% (HPLC)
Biological Activity for IPAG
IPAG is a potent σ-receptor antagonist.
Technical Data for IPAG
| M. Wt | 395.29 |
| Formula | C17H22IN3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 193527-91-2 |
| PubChem ID | 4239764 |
| InChI Key | UUKPIWYXWLJPJF-UHFFFAOYSA-N |
| Smiles | IC1=CC=C(NC(=N)NC2C3CC4CC(C3)CC2C4)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for IPAG
References for IPAG
References are publications that support the biological activity of the product.
Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867 PMID: 1648140
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Keywords: IPAG, IPAG supplier, Potent, σ, sigma, antagonists, General, Receptors, Sigma-Related, 0544, Tocris Bioscience
2 Citations for IPAG
Citations are publications that use Tocris products. Selected citations for IPAG include:
Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888
Brimson et al (2011) Antagonists show GTP-sensitive high-affinity binding to the sigma-1 receptor. Br J Pharmacol 164 772 PMID: 21486275
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