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Submit Review(S)-(-)-5-Iodowillardiine
Description: Highly potent and subtype-selective kainate agonist
Purity: ≥98% (HPLC)
Biological Activity for (S)-(-)-5-Iodowillardiine
Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for (S)-(-)-5-Iodowillardiine
| M. Wt | 325.06 |
| Formula | C7H8IN3O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 140187-25-3 |
| PubChem ID | 447196 |
| InChI Key | AXXYLTBQIQBTES-BYPYZUCNSA-N |
| Smiles | O=C(N1)N(C[C@]([H])(N)C(O)=O)C=C(I)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (S)-(-)-5-Iodowillardiine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 8.12 | 25 |
Preparing Stock Solutions for (S)-(-)-5-Iodowillardiine
The following data is based on the product molecular weight 325.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 12.31 mL | 61.53 mL | 123.05 mL |
| 1.25 mM | 2.46 mL | 12.31 mL | 24.61 mL |
| 2.5 mM | 1.23 mL | 6.15 mL | 12.31 mL |
| 12.5 mM | 0.25 mL | 1.23 mL | 2.46 mL |
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Product Datasheets for (S)-(-)-5-Iodowillardiine
References for (S)-(-)-5-Iodowillardiine
References are publications that support the biological activity of the product.
Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645 PMID: 9357531
Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595 PMID: 1371315
Swanson et al (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 53 942 PMID: 9584222
Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881 PMID: 7515954
Thompson et al (1996) Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol. 117 331P
If you know of a relevant reference for (S)-(-)-5-Iodowillardiine, please let us know.
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Keywords: (S)-(-)-5-Iodowillardiine, (S)-(-)-5-Iodowillardiine supplier, potent, subtype, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, GluR5, GluK1, 0307, Tocris Bioscience
2 Citations for (S)-(-)-5-Iodowillardiine
Citations are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:
Pollok and Reiner (2020) Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proc Natl Acad Sci U S A 117 25851 PMID: 32999066
Pansiot et al (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. Proc Natl Acad Sci U S A 5 e10916 PMID: 20532231
Do you know of a great paper that uses (S)-(-)-5-Iodowillardiine from Tocris? Please let us know.
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