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Submit ReviewCGRP 8-37 (rat)
Description: CGRP antagonist
Alternative Names: Calcitonin Gene-Related Peptide 8-37 (rat)
Purity: ≥95% (HPLC)
Biological Activity for CGRP 8-37 (rat)
CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors.
Technical Data for CGRP 8-37 (rat)
| M. Wt | 3127.5 |
| Formula | C138H224N42O41 |
| Sequence |
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF (Modification: Phe-30 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 129121-73-9 |
| PubChem ID | 90479762 |
| InChI Key | HZKKKBMPFPSSKZ-QZMRZBIOSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGRP 8-37 (rat)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for CGRP 8-37 (rat)
References for CGRP 8-37 (rat)
References are publications that support the biological activity of the product.
Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424 PMID: 8578616
Poyner et al (1998) Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 124 1659 PMID: 9756381
Wisskirchen et al (1998) Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 123 1673 PMID: 9605575
If you know of a relevant reference for CGRP 8-37 (rat), please let us know.
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5 Citations for CGRP 8-37 (rat)
Citations are publications that use Tocris products. Selected citations for CGRP 8-37 (rat) include:
Cowie et al (2018) Optogenetic Inhibition of CGRPα Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain. J Neurosci 38 5807 PMID: 29925650
Khodorova et al (2009) Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1. J Pain 10 740 PMID: 19559390
Tozzi et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A 109 18985 PMID: 23112192
Zhang et al (2019) Role of intraganglionic transmission in the trigeminovascular pathway. Mol Pain 15 1744806919836570 PMID: 30784351
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Cell Mol Med 315 1380 PMID: 16160082
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.