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Submit ReviewNaloxone benzoylhydrazone
Description: Full κ agonist, partial μ and δ agonist and antagonizes agonist-induced activation of NOP
Alternative Names: NalBzOH
Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide
Purity: ≥99% (HPLC)
Biological Activity for Naloxone benzoylhydrazone
Naloxone benzoylhydrazone is a mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.
Technical Data for Naloxone benzoylhydrazone
| M. Wt | 445.52 |
| Formula | C26H27N3O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 119630-94-3 |
| PubChem ID | 9601084 |
| InChI Key | AKXCFAYOTIEFOH-XTNAHFASSA-N |
| Smiles | O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Naloxone benzoylhydrazone
References for Naloxone benzoylhydrazone
References are publications that support the biological activity of the product.
Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349 PMID: 16402044
Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469 PMID: 2553921
Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360 PMID: 16402046
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Keywords: Naloxone benzoylhydrazone, Naloxone benzoylhydrazone supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, NalBzOH, Miscellaneous/Non-selective, 1419, Tocris Bioscience
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