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Submit ReviewTriacsin C
Description: Inhibitor of acyl-CoA synthetase
Chemical Name: (2E,4E,7E)-2,4,7-Undecatrienal nitrosohydrazone
Purity: ≥95% (HPLC)
Biological Activity for Triacsin C
Triacsin C is an inhibitor of acyl-CoA synthetase. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.
Technical Data for Triacsin C
| M. Wt | 207.27 |
| Formula | C11H17N3O |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 76896-80-5 |
| PubChem ID | 9576787 |
| InChI Key | NKTGCVUIESDXPU-YLEPRARLSA-N |
| Smiles | O=NN/N=C/C=C/C=C/C/C=C/CCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Triacsin C
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5 | 25 |
Preparing Stock Solutions for Triacsin C
The following data is based on the product molecular weight 207.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 19.3 mL | 96.49 mL | 192.98 mL |
| 1.25 mM | 3.86 mL | 19.3 mL | 38.6 mL |
| 2.5 mM | 1.93 mL | 9.65 mL | 19.3 mL |
| 12.5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
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Product Datasheets for Triacsin C
References for Triacsin C
References are publications that support the biological activity of the product.
Tomoda et al (1991) Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. J.Biol.Chem. 266 4214 PMID: 1999415
Mashima et al (2005) p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J.Natl.Cancer.Inst. 97 765 PMID: 15900046
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Keywords: Triacsin C, Triacsin C supplier, Triacsin, C, inhibitors, inhibits, acyl-coa-synthetase, antitumor, Other, Synthases/Synthetases, 2472, Tocris Bioscience
1 Citation for Triacsin C
Citations are publications that use Tocris products. Selected citations for Triacsin C include:
Lancaster et al (2018) Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism. Cell Metab 27 1096 PMID: 29681442
Do you know of a great paper that uses Triacsin C from Tocris? Please let us know.
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