Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEdaravone
Description: Anti-ischemic and antioxidant
Alternative Names: MCI-186
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity: ≥99% (HPLC)
Biological Activity for Edaravone
Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.
Technical Data for Edaravone
| M. Wt | 174.2 |
| Formula | C10H10N2O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 89-25-8 |
| PubChem ID | 4021 |
| InChI Key | QELUYTUMUWHWMC-UHFFFAOYSA-N |
| Smiles | CC1=NN(C(=O)C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Edaravone
References for Edaravone
References are publications that support the biological activity of the product.
Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921 PMID: 9152402
Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274 PMID: 17429058
Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597 PMID: 8138971
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
View Related Products by Target
Keywords: Edaravone, Edaravone supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, MCI-186, Antioxidants, Autophagy, 0786, Tocris Bioscience
3 Citations for Edaravone
Citations are publications that use Tocris products. Selected citations for Edaravone include:
Walton et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7 e35264 PMID: 22558133
Tsunekawa et al (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol 14 4 PMID: 23289926
Wu et al (2019) Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways. PLoS One 14 e0209426 PMID: 30645596
Reviews for Edaravone
There are currently no reviews for this product. Be the first to review Edaravone and earn rewards!
Have you used Edaravone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image