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Submit ReviewSR 11302
Description: AP-1 inhibitor; antitumor agent
Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Purity: ≥95% (HPLC)
Biological Activity for SR 11302
SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
Technical Data for SR 11302
| M. Wt | 376.54 |
| Formula | C26H32O2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 160162-42-5 |
| PubChem ID | 9976842 |
| InChI Key | RQANARBNMTXCDM-DKOHIBGUSA-N |
| Smiles | CC(\C=C\C=C(\C=C\C1=C(C)CCCC1(C)C)C1=CC=C(C)C=C1)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 11302
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.6 | 100 | |
| ethanol | 3.76 | 10 |
Preparing Stock Solutions for SR 11302
The following data is based on the product molecular weight 376.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.66 mL | 13.28 mL | 26.56 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.66 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for SR 11302
References for SR 11302
References are publications that support the biological activity of the product.
Shiohara et al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057 PMID: 10068679
Huang et al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94 5826
Fanjul et al (1994) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107 PMID: 7969403
If you know of a relevant reference for SR 11302, please let us know.
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Keywords: SR 11302, SR 11302 supplier, inhibitors, inhibits, AP-1, transcription, factors, antitumor, agent, SR11302, 2476, Tocris Bioscience
26 Citations for SR 11302
Citations are publications that use Tocris products. Selected citations for SR 11302 include:
Bawazeer and Theoharides (2019) IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur J Pharmacol 865 PMID: 31669588
Kim et al (2018) Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep 25 2148 PMID: 30463012
Han et al (2018) TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways. Am J Cancer Res 8 489 PMID: 29637003
Lee et al (2016) Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II. PLoS One 11 e0163415 PMID: 27658294
Huang et al (2015) p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Int J Gynecol Cancer 3 225 PMID: 25798247
Chen et al (2015) Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway. Sci Rep 25 953 PMID: 26098087
Zheng et al (2015) The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization. Invest Ophthalmol Vis Sci 5 14408 PMID: 26404494
Kim et al (2014) Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol 44 807 PMID: 24338737
Bakhru et al (2014) BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol 287 53 PMID: 24384074
Mason et al (2014) Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells. Drug Metab Dispos 42 2077 PMID: 25261564
O'Sullivan et al (2014) Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One 9 e95566 PMID: 24743449
Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105 PMID: 25290234
Kleiner et al (2018) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis 24 647 PMID: 30310263
Sethi et al (2011) Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. PLoS One 52 5240 PMID: 21546528
Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249
Zhang et al (2018) Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance. J Biol Chem 293 1030 PMID: 29203528
Sun et al (2017) Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med 214 1753 PMID: 28465464
Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048 PMID: 25848047
Banskota et al (2015) NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. Mol Cancer 14 123 PMID: 26116564
Lee et al (2015) Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression. Oncotarget 6 22139 PMID: 26061816
Ivanova et al (2011) Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J 25 1402 PMID: 21233487
Messerschmidt et al (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis 25 329 PMID: 31341381
Nadeau-Vallée et al (2015) Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J Immunol 195 3402 PMID: 26304990
Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126
Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519 PMID: 23918927
Bugel et al (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296 31 PMID: 26908177
Do you know of a great paper that uses SR 11302 from Tocris? Please let us know.
Reviews for SR 11302
Average Rating: 5 (Based on 2 Reviews.)
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Exploration of AP-1 as a mediator of apoptosis.
By
MARINA KOUTSIOUMPA on 10/13/2022
Assay Type: In Vitro
Species: Human
The inhibitor of activator protein-1 (AP-1) transcription factor was used to explore the role of AP-1 in drug-induced apoptosis of cancer cell lines. Results were consistent.
HSC mediate activator protein-1 (AP-1) transcription factor activity on acute liver injury.
By
sudhir kumar on 01/04/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hepatic stellate cells
Effect of (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid) drug after HSC treatment.
