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Description: Potent inhibitor of L-glutamate uptake. Less activity as a substrate compared to its parent compound, L-trans-2,4-PDC (Cat. No. 0298)
Chemical Name: L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid
Biological Activity for MPDC
Potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter.
Technical Data for MPDC
| M. Wt | 171.15 |
| Formula | C7H9NO4 |
| Storage | Store at RT |
| CAS Number | 159262-32-5 |
| PubChem ID | 6604785 |
| InChI Key | UNNFLFDQCHJXPI-QTBDOELSSA-N |
| Smiles | [H][C@]1([C@H]2[C@@](O)=O)[C@]2([H])CN[C@@H]1[C@](O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MPDC
References for MPDC
References are publications that support the biological activity of the product.
Bridges et al (1994) A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine carboxylate. Neurosci.Lett. 174 193 PMID: 7970177
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Keywords: MPDC, MPDC supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0973, Tocris Bioscience
Citations for MPDC
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Currently there are no citations for MPDC.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.