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Submit ReviewOlomoucine
Description: Cdk inhibitor
Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Biological Activity for Olomoucine
ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.
Technical Data for Olomoucine
| M. Wt | 298.35 |
| Formula | C15H18N6O |
| Storage | Desiccate at -20°C |
| CAS Number | 101622-51-9 |
| PubChem ID | 4592 |
| InChI Key | GTVPOLSIJWJJNY-UHFFFAOYSA-N |
| Smiles | CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Olomoucine
References for Olomoucine
References are publications that support the biological activity of the product.
Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105 PMID: 7549905
Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8 PMID: 9828096
Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771 PMID: 7925396
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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Keywords: Olomoucine, Olomoucine supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Kinase, 1284, Tocris Bioscience
1 Citation for Olomoucine
Citations are publications that use Tocris products. Selected citations for Olomoucine include:
Cannon et al (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab 296 E1392 PMID: 19293332
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.