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Submit ReviewCCK Octapeptide, sulfated
Description: C-terminal octapeptide of CCK
Alternative Names: Cholecystokinin Octapeptide,sulfated,CCK-8
Purity: ≥95% (HPLC)
Biological Activity for CCK Octapeptide, sulfated
CCK Octapeptide, sulfated is an endogenous C-terminal octapeptide of CCK found in the central nervous system and gastrointestinal tract.
Non-sulfated Peptide also available.
Technical Data for CCK Octapeptide, sulfated
| M. Wt | 1142.2 |
| Formula | C49H62N10O16S3 |
| Sequence |
DYMGWMDF (Modifications: Tyr-2 = SO3H, Phe-8 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 25126-32-3 |
| PubChem ID | 9833444 |
| InChI Key | IZTQOLKUZKXIRV-YRVFCXMDSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(OS(O)(=O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CCK Octapeptide, sulfated
| Solubility | Soluble to 0.50 mg/ml in PBS (pH 7.4) with sonication |
Product Datasheets for CCK Octapeptide, sulfated
References for CCK Octapeptide, sulfated
References are publications that support the biological activity of the product.
Beinfel (1997) CCK biosynthesis and processing: recent progress and future challenges. Life Sci. 61 2359 PMID: 9399627
Gaw et al (1995) Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat. Br.J.Pharmacol. 115 660 PMID: 7582487
Heinemann et al (1995) Mediation by CCKB receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br.J.Pharmacol. 116 2274 PMID: 8564259
Wank (1998) G-protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am.J.Physiol. 274 G607 PMID: 9575840
If you know of a relevant reference for CCK Octapeptide, sulfated, please let us know.
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Keywords: CCK Octapeptide, sulfated, CCK Octapeptide, sulfated supplier, C-terminal, octapeptide, CCK, Cholecystokinin, Non-Selective, Receptors, agonists, CCK-8, CCK8, Octapeptide,, sulfated, Non-selective, 1166, Tocris Bioscience
8 Citations for CCK Octapeptide, sulfated
Citations are publications that use Tocris products. Selected citations for CCK Octapeptide, sulfated include:
Caquineau et al (2010) Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats. Autophagy 22 446 PMID: 20163516
D'Agostino et al (2016) Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Regul Pept 5 PMID: 26974347
Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417
Reidelberger et al (2014) Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats. Am J Physiol Endocrinol Metab 307 E619 PMID: 25117406
Gamble et al (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. J Neuroendocrinol 185 41518 PMID: 23816469
Wang et al (2019) TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons. JCI Insight 4 PMID: 30843875
Hisadome et al (2011) CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes 60 2701 PMID: 21885869
Wang et al (2019) A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding. Nat Commun 10 2769 PMID: 31235690
Do you know of a great paper that uses CCK Octapeptide, sulfated from Tocris? Please let us know.
Reviews for CCK Octapeptide, sulfated
Average Rating: 4 (Based on 1 Review.)
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Applied to colon tissue.
By
John Broad on 01/05/2018
Assay Type: In Vitro
Species: Human
1uM CCK contracts GI smooth muscle
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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