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Description: Novel, non-toxic immunosuppressive agent
Alternative Names: NSC 631156
Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
Purity: ≥99% (HPLC)
Biological Activity for MNITMT
MNITMT is a novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
Previously sold as Cat. No. 0564.
Technical Data for MNITMT
| M. Wt | 240.24 |
| Formula | C7H8N6O2S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 177653-76-8 |
| PubChem ID | 364622 |
| InChI Key | NMBDIMPYACLUDE-UHFFFAOYSA-N |
| Smiles | CN1C=NN=C1SC1=C(N=CN1C)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MNITMT
References for MNITMT
References are publications that support the biological activity of the product.
Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathio. lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690 PMID: 8709098
Al-Safi et al (2003) Comparison of the effects of azathio. and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239 PMID: 12926553
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Keywords: MNITMT, MNITMT supplier, Immunosuppressant, NSC631156, NSC, 631156, Immunosuppressants, 2492, Tocris Bioscience
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