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Submit ReviewDR 2313
Description: PARP-1 and PARP-2 inhibitor
Chemical Name: 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥99% (HPLC)
Biological Activity for DR 2313
DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.
Technical Data for DR 2313
| M. Wt | 182.24 |
| Formula | C8H10N2OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 284028-90-6 |
| PubChem ID | 10219702 |
| InChI Key | HRYKZAKEAVZGJD-UHFFFAOYSA-N |
| Smiles | CC1=NC(=O)C2=C(N1)CCSC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DR 2313
References for DR 2313
References are publications that support the biological activity of the product.
Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472 PMID: 15466246
Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421 PMID: 15864271
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Keywords: DR 2313, DR 2313 supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Poly(ADP-ribose), 2496, Tocris Bioscience
Citations for DR 2313
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