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Submit ReviewIrsogladine maleate
Description: PDE4 inhibitor; antiulcer agent
Alternative Names: MN 1695
Chemical Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
Purity: ≥99% (HPLC)
Biological Activity for Irsogladine maleate
Irsogladine maleate is a phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Technical Data for Irsogladine maleate
| M. Wt | 372.18 |
| Formula | C9H7Cl2N5.C4H4O4 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 84504-69-8 |
| PubChem ID | 5282435 |
| InChI Key | PJLVTVAIERNDEQ-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.NC1=NC(=NC(N)=N1)C1=CC(Cl)=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Irsogladine maleate
References for Irsogladine maleate
References are publications that support the biological activity of the product.
Nozaki et al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195 PMID: 14758089
Kyoi et al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321 PMID: 15272207
Kyoi et al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71 PMID: 15501481
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Keywords: Irsogladine maleate, Irsogladine maleate supplier, PDE4, inhibitors, inhibits, antiulcer, agent, Phosphodiesterases, MN1695, MN, 1695, 2504, Tocris Bioscience
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