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Submit ReviewTalniflumate
Discontinued Product
2510 has been discontinued.
View all Calcium-activated Chloride Channels products.
Description: CaCC blocker and Cl-/HCO3- exchange inhibitor
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Purity: ≥99% (HPLC)
Biological Activity for Talniflumate
Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Technical Data for Talniflumate
| M. Wt | 414.34 |
| Formula | C21H13F3N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 66898-62-2 |
| PubChem ID | 48229 |
| InChI Key | ANMLJLFWUCQGKZ-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Talniflumate
References for Talniflumate
References are publications that support the biological activity of the product.
Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791
Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42
Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557
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Keywords: Talniflumate, Talniflumate supplier, Cyclooxygenase, inhibitors, inhibits, chloride, channels, blockers, Chloride, hCLCA1/mCLCA3, COX, Oxygenases, Oxidases, Cl-/HCO3-, exchangers, CaCC, calcium-activated, Ca2+-Activated, Channels, 2510, Tocris Bioscience
Citations for Talniflumate
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Currently there are no citations for Talniflumate.
Reviews for Talniflumate
Average Rating: 5 (Based on 1 Review.)
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Activity evaluation of Talniflumate carried out..
By
Anonymous on 08/26/2019
Species: Human
Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.
Cells were were incubated with different concentrations of Talniflumate (50, 100, 150 and 200 mkM), gefitinib and the combination of talniflumate and gefitinib for 24h.
Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Talniflumate
