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Submit ReviewAcyclovir
Description: Inhibits viral DNA polymerase; antiherpetic agent
Alternative Names: Aciclovir,Acycloguanosine
Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Purity: ≥99% (HPLC)
Biological Activity for Acyclovir
Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
Compound Libraries for Acyclovir
Acyclovir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Acyclovir
| M. Wt | 225.21 |
| Formula | C8H11N5O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 59277-89-3 |
| PubChem ID | 2022 |
| InChI Key | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| Smiles | NC1=NC(=O)C2=C(N1)N(COCCO)C=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Acyclovir
References for Acyclovir
References are publications that support the biological activity of the product.
Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868
Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734
Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716
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Keywords: Acyclovir, Acyclovir supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, Polymerase, DNA,, RNA, and, Protein, Herpes, Simplex, Viruses, 2513, Tocris Bioscience
Citations for Acyclovir
Citations are publications that use Tocris products.
Currently there are no citations for Acyclovir.
Reviews for Acyclovir
Average Rating: 4 (Based on 1 Review.)
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Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
By
Anonymous on 08/18/2019
Species: Human
Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.