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Submit ReviewFG 7142
Description: Benzodiazepine inverse agonist
Chemical Name: N-Methyl-β-carboline-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for FG 7142
FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.
Compound Libraries for FG 7142
FG 7142 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for FG 7142
| M. Wt | 225.25 |
| Formula | C13H11N3O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 78538-74-6 |
| PubChem ID | 4375 |
| InChI Key | QMCOPDWHWYSJSA-UHFFFAOYSA-N |
| Smiles | CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FG 7142
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 16.89 | 75 | |
| DMSO | 22.52 | 100 |
Preparing Stock Solutions for FG 7142
The following data is based on the product molecular weight 225.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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Product Datasheets for FG 7142
References for FG 7142
References are publications that support the biological activity of the product.
Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352 PMID: 2478895
Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355 PMID: 2765936
Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313 PMID: 3032657
Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219 PMID: 2498110
If you know of a relevant reference for FG 7142, please let us know.
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Keywords: FG 7142, FG 7142 supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, 0554, Tocris Bioscience
4 Citations for FG 7142
Citations are publications that use Tocris products. Selected citations for FG 7142 include:
Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753 PMID: 19837095
Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719 PMID: 22583860
Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1 PMID: 22297173
Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733 PMID: 22554617
Do you know of a great paper that uses FG 7142 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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