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Description: Selective inhibitor of E-selectin and ICAM-1 expression
Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for A 205804
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
Technical Data for A 205804
| M. Wt | 300.39 |
| Formula | C15H12N2OS2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 251992-66-2 |
| PubChem ID | 9839311 |
| InChI Key | QQGWEXFLMJGCAL-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 205804
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.04 | 100 | |
| ethanol | 3 | 10 |
Preparing Stock Solutions for A 205804
The following data is based on the product molecular weight 300.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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Product Datasheets for A 205804
References for A 205804
References are publications that support the biological activity of the product.
Stewart et al (2001) Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J.Med.Chem. 44 988 PMID: 11300880
Zhu et al (2001) Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J.Med.Chem. 44 3469 PMID: 11585452
Zhu et al (2002) Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. J.Org.Chem. 67 943 PMID: 11856042
If you know of a relevant reference for A 205804, please let us know.
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Keywords: A 205804, A 205804 supplier, Selective, inhibitors, inhibits, E-selectin, ICAM-1, Adhesion, Molecules, A205804, Cell, Integrins, 2524, Tocris Bioscience
1 Citation for A 205804
Citations are publications that use Tocris products. Selected citations for A 205804 include:
Othumpangat et al (2016) ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection. Virology 487 85 PMID: 26499045
Do you know of a great paper that uses A 205804 from Tocris? Please let us know.
Reviews for A 205804
Average Rating: 5 (Based on 1 Review.)
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ICAM-1 inhibitor A 205804 show the highest increase in matrix copy number.
By
Anonymous on 10/20/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HBEpC
We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A205804(TOCRIS),whereas 50ng/mL showed the highest(100%)increase in matrix copy number compared to the DMSO treatedcontrol cells infected with influenza virus
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