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Submit Review(S)-Methylisothiourea sulfate
Description: Highly selective iNOS inhibitor
Alternative Names: SMT
Biological Activity for (S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate is a highly selective, potent competitive inhibitor of iNOS.
Technical Data for (S)-Methylisothiourea sulfate
| M. Wt | 278.36 |
| Formula | C4H14N4O4S3 |
| Storage | Store at RT |
| CAS Number | 867-44-7 |
| PubChem ID | 13347 |
| InChI Key | BZZXQZOBAUXLHZ-UHFFFAOYSA-N |
| Smiles | NC(SC)=[NH2+].NC(SC)=[NH2+].[O-]S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (S)-Methylisothiourea sulfate
References for (S)-Methylisothiourea sulfate
References are publications that support the biological activity of the product.
Iuvone et al (1997) Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br.J.Pharmacol. 121 1637 PMID: 9283697
Southan et al (1995) Isothioureas - potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br.J.Pharmacol. 114 510 PMID: 7533622
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Keywords: (S)-Methylisothiourea sulfate, (S)-Methylisothiourea sulfate supplier, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, SMT, 0776, Tocris Bioscience
2 Citations for (S)-Methylisothiourea sulfate
Citations are publications that use Tocris products. Selected citations for (S)-Methylisothiourea sulfate include:
Chan et al (2007) Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71 1129 PMID: 17227955
Chang et al (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol 136 43313 PMID: 11976262
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