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Submit ReviewKisspeptin 10 (human)
Description: Endogenous ligand for kisspeptin receptor
Alternative Names: Metastin (45-54),Kp-10
Purity: ≥95% (HPLC)
Biological Activity for Kisspeptin 10 (human)
Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.
Analog also available.
Technical Data for Kisspeptin 10 (human)
| M. Wt | 1302.45 |
| Formula | C63H83N17O14 |
| Sequence |
YNWNSFGLRF (Modification: Phe-10 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 374675-21-5 |
| PubChem ID | 25240297 |
| InChI Key | RITKWYDZSSQNJI-INXYWQKQSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kisspeptin 10 (human)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Kisspeptin 10 (human)
References for Kisspeptin 10 (human)
References are publications that support the biological activity of the product.
Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843
Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE. Endocrinology 149 1979 PMID: 18162521
Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677
If you know of a relevant reference for Kisspeptin 10 (human), please let us know.
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Keywords: Kisspeptin 10 (human), Kisspeptin 10 (human) supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, (45-54), Kp-10, Kisspeptin, Receptor, 2570, Tocris Bioscience
5 Citations for Kisspeptin 10 (human)
Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:
Wu et al (2013) Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26 1080 PMID: 25049888
Wu et al (2012) Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci 25 1229 PMID: 25049685
Constantin and Wray (2016) Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology 157 3197 PMID: 27359210
Schwetz et al (2014) Differential stimulation of Ins secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020 PMID: 25401335
Ji et al (2014) Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. Autophagy 14 723 PMID: 25260785
Do you know of a great paper that uses Kisspeptin 10 (human) from Tocris? Please let us know.
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