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Submit ReviewZamifenacin fumarate
Description: Selective M3 antagonist
Alternative Names: UK 76654
Chemical Name: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate
Purity: ≥99% (HPLC)
Biological Activity for Zamifenacin fumarate
Selective M3 muscarinic receptor antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively). Displays higher affinity at ileal M3 receptors (pKi = 9.3) compared to oesophageal and tracheal M3 receptors (pKi values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects.
Technical Data for Zamifenacin fumarate
| M. Wt | 531.6 |
| Formula | C27H29NO3.C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 127308-98-9 |
| PubChem ID | 20056967 |
| InChI Key | PMHKTAIGYOVZEZ-ZHWJIHCSSA-N |
| Smiles | C1(CCN3C[C@H](OC(C5=CC=CC=C5)C4=CC=CC=C4)CCC3)=CC=C(OCO2)C2=C1.C(\C=C\C(O[H])=O)(O[H])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Zamifenacin fumarate
References for Zamifenacin fumarate
References are publications that support the biological activity of the product.
Wallis (1995) Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists. Life Sci. 56 861 PMID: 10188786
Watson et al (1995) Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur.J.Pharmacol. 285 135 PMID: 8566131
Choppin (2002) Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains. Br.J.Pharmacol. 137 522 PMID: 12359634
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Keywords: Zamifenacin fumarate, Zamifenacin fumarate supplier, Selective, M3, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, UK76654, UK, 76654, 2579, Tocris Bioscience
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