Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMinoxidil
Description: Kir6 channel (KATP) opener
Chemical Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Purity: ≥99% (HPLC)
Biological Activity for Minoxidil
Minoxidil is an antihypertensive. Antialopecia agent. Kir6 channel (KATP) activator.
Compound Libraries for Minoxidil
Minoxidil is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Minoxidil
| M. Wt | 209.25 |
| Formula | C9H15N5O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 38304-91-5 |
| PubChem ID | 4201 |
| InChI Key | ZIMGGGWCDYVHOY-UHFFFAOYSA-N |
| Smiles | NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Minoxidil
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 5.23 | 25 | |
| DMSO | 5.23 | 25 with gentle warming |
Preparing Stock Solutions for Minoxidil
The following data is based on the product molecular weight 209.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 19.12 mL | 95.58 mL | 191.16 mL |
| 1.25 mM | 3.82 mL | 19.12 mL | 38.23 mL |
| 2.5 mM | 1.91 mL | 9.56 mL | 19.12 mL |
| 12.5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Minoxidil
References for Minoxidil
References are publications that support the biological activity of the product.
Lachgar et al (1998) Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br.J.Dermatol. 138 407 PMID: 9580790
Meisheri et al (1993) Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem.Pharmacol. 45 271 PMID: 8435087
Tsoporis et al (1993) Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats. J.Hypertens. 11 1337 PMID: 8133016
Merck Index 12 6290
If you know of a relevant reference for Minoxidil, please let us know.
View Related Products by Target
View Related Products by Product Action
View all Inward Rectifier Potassium (Kir) Channel Activators
Keywords: Minoxidil, Minoxidil supplier, K+, channel, KATP, openers, Potassium, KIR, Channels, Inward, Rectifier, antihypertensive, activators, Kir6, rectifier, 0583, Tocris Bioscience
1 Citation for Minoxidil
Citations are publications that use Tocris products. Selected citations for Minoxidil include:
Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792
Do you know of a great paper that uses Minoxidil from Tocris? Please let us know.
Reviews for Minoxidil
Average Rating: 5 (Based on 1 Review.)
Have you used Minoxidil?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Minoxidil used to study BK channel opening.
By
Sadequl Islam on 11/27/2018
Assay Type: In Vitro
Species: Human
Minoxidil was used based on its history as a potent potassium channel opener. It was used to study BK channel opening.
