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Submit ReviewMM 77 dihydrochloride
Description: 5-HT1A (postsynaptic) antagonist
Chemical Name: 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine dihydrochloride
Biological Activity for MM 77 dihydrochloride
MM 77 dihydrochloride is a highly potent and fairly selective 5-HT1A ligand, which may be a full antagonist at postsynaptic receptors.
Technical Data for MM 77 dihydrochloride
| M. Wt | 418.36 |
| Formula | C19H27N3O3.2HCl |
| Storage | Store at RT |
| CAS Number | 159187-70-9 |
| PubChem ID | 45073441 |
| InChI Key | ZYCVVOZXHNDRCO-UHFFFAOYSA-N |
| Smiles | Cl.Cl.COC1=CC=CC=C1N1CCN(CCCCN2C(=O)CCC2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MM 77 dihydrochloride
References for MM 77 dihydrochloride
References are publications that support the biological activity of the product.
Mokrosz et al (1994) 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine (MM 77): a new, potent, postsynaptic antagonist of 5-HT1A receptors. Med.Chem.Res. 4 161
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Citations for MM 77 dihydrochloride
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Currently there are no citations for MM 77 dihydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.