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Submit ReviewCompstatin
Description: C3-binding peptide; inhibits complement activation
Purity: ≥95% (HPLC)
Biological Activity for Compstatin
Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.
Control Peptide also available.
Technical Data for Compstatin
| M. Wt | 1550.77 |
| Formula | C66H99N23O17S2 |
| Sequence |
ICVVQDWGHHRCT (Modifications: Thr-13 = C-terminal amide, Disulfide bridge: 2-12) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 206645-99-0 |
| PubChem ID | 25082538 |
| InChI Key | RDTRHBCZFDCUPW-KWICJJCGSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Compstatin
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Compstatin
References for Compstatin
References are publications that support the biological activity of the product.
Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884 PMID: 8752942
Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52 PMID: 10355733
Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212 PMID: 10964539
If you know of a relevant reference for Compstatin, please let us know.
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Keywords: Compstatin, Compstatin supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Complement, 2585, Tocris Bioscience
7 Citations for Compstatin
Citations are publications that use Tocris products. Selected citations for Compstatin include:
Larsen et al (2019) Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Front Immunol 9 3088 PMID: 30666256
Sharma et al (2021) Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun 12 7293 PMID: 34911940
Yang et al (2009) Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the IF.-inducible immunoproteasome. Arterioscler Thromb Vasc Biol 29 1213 PMID: 19443843
Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342 PMID: 23661042
Koupenova et al (2019) The role of platelets in mediating a response to human influenza infection. Nat Commun 10 1780 PMID: 30992428
Sun et al (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect 7 e35415 PMID: 22567103
Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192 PMID: 24763049
Do you know of a great paper that uses Compstatin from Tocris? Please let us know.
Reviews for Compstatin
Average Rating: 4 (Based on 1 Review.)
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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein.
By
Ahsan Habib on 01/06/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: CHO/APPwt
We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.