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Discontinued Product
0853 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Group III and group II mGlu antagonist; more selective for group III than group II
Chemical Name: (RS)-α-Methyl-4-phosphonophenylglycine
Biological Activity for MPPG
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices.
Technical Data for MPPG
| M. Wt | 245.17 |
| Formula | C9H12NO5P |
| Storage | Store at RT |
| CAS Number | 169209-65-8 |
| PubChem ID | 3972752 |
| InChI Key | PAONCRJPUQXPRW-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)(C)C1=CC=C(P(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MPPG
Certificate of Analysis is currently unavailable on-line.
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References for MPPG
References are publications that support the biological activity of the product.
Bedingfield et al (1996) Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 309 71 PMID: 8864696
Bushell et al (1996) Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 117 1457 PMID: 8730739
Jane et al (1995) New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 851 PMID: 8532166
Salt and Turner (1996) Antagonism of the presumed presynaptic action of L-AP4 on GABAergic transmission in the ventrobasal thalamus by the novel mGluR anatagonist MPPG. Neuropharmacology 35 239 PMID: 8734494
View Related Products by Target
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View all Glutamate (Metabotropic) Group III Receptor Antagonists
Keywords: MPPG, MPPG supplier, Group, III, group, II, mGlur, antagonists, selective, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, (Metabotropic), 0853, Tocris Bioscience
1 Citation for MPPG
Citations are publications that use Tocris products. Selected citations for MPPG include:
Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Mol Cancer Res 10 e0125974 PMID: 25933382
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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