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Submit ReviewPD 168368
Description: Selective neuromedin B receptor antagonist (NMB-R, BB1)
Chemical Name: (S)-α-Methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]-1H-indole-3-propanamide
Purity: ≥96% (HPLC)
Biological Activity for PD 168368
Potent neuromedin B receptor antagonist (NMB-R, BB1) (IC50 = 40 nM) that displays ~ 40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB2) and > 300-fold selectivity over BRS-R (bb3). Antagonizes neuromedin B-stimulated calcium release and inhibits proliferation of rat glioma cells (IC50 = 2 μM).
Technical Data for PD 168368
| M. Wt | 554.65 |
| Formula | C31H34N6O4 |
| Storage | Store at +4°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 204066-82-0 |
| Smiles | O=C(NC3=CC=C([N+]([O-])=O)C=C3)N[C@@](C)(CC5=CNC4=CC=CC=C45)C(NCC1(C2=CC=CC=N2)CCCCC1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 168368
References for PD 168368
References are publications that support the biological activity of the product.
Ryan et al (1999) Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368 J.Pharmacol.Exp.Ther. 290 1202 PMID: 10454496
Moody et al (2000) Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. Eur.J.Pharmacol. 409 133 PMID: 11104826
Moody et al (2003) Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. Eur.J.Pharmacol. 474 21 PMID: 12909192
Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists pD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol.Pharmacol. 79 77 PMID: 20943772
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Keywords: PD 168368, PD 168368 supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Bombesin, PD168368, Receptors, 2603, Tocris Bioscience
Citations for PD 168368
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