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Submit ReviewNaloxonazine dihydrochloride
Discontinued Product
0591 has been discontinued.
Description: Selective μ1 antagonist
Chemical Name: Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Naloxonazine dihydrochloride
Naloxonazine dihydrochloride is a potent opioid antagonist, selective for μ1 receptors.
Technical Data for Naloxonazine dihydrochloride
| M. Wt | 723.69 |
| Formula | C38H42N4O6.2HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 880759-65-9 |
| PubChem ID | 90479735 |
| InChI Key | VIAIHLLKDJKEKM-DCBBKWFGSA-N |
| Smiles | [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\N=C6CC[C@]7([C@]8(CC9=C%10C(O[C@@]/6([C@@]7%10CCN8CC=C)[H])=C(C=C9)O)[H])O)O)[H])CC=C)O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Naloxonazine dihydrochloride
References for Naloxonazine dihydrochloride
References are publications that support the biological activity of the product.
Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168
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Keywords: Naloxonazine dihydrochloride, Naloxonazine dihydrochloride supplier, Selective, antagonists, μ-opioid, mu-opioid, μ1-opioid, mu1-opioid, MOP, Receptors, OP3, Mu, Opioid, 0591, Tocris Bioscience
4 Citations for Naloxonazine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Naloxonazine dihydrochloride include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol 22 49 PMID: 26150021
Smith et al (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A 113 13893 PMID: 27849613
Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci 2012 941685 PMID: 22645476
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