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Submit ReviewNaltriben mesylate
Discontinued Product
0892 has been discontinued.
Description: Standard δ2 selective antagonist
Chemical Name: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate
Purity: ≥98% (HPLC)
Biological Activity for Naltriben mesylate
Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Displays selectivity for the δ2 subtype in vivo.
Licensing Information
Sold with the permission of the University of Minnesota
Technical Data for Naltriben mesylate
| M. Wt | 511.59 |
| Formula | C26H25NO4.CH3SO3H |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 122517-78-6 |
| PubChem ID | 45073482 |
| InChI Key | XRRFZOCDAWPIBB-IDRHMUJXSA-N |
| Smiles | C[S](O)(=O)=O.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CC1=C2OC2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Naltriben mesylate
References for Naltriben mesylate
References are publications that support the biological activity of the product.
Miyamoto et al (1993) Involvement of delta2 opioid receptors in the development of mor. dependence in mice. J.Pharmacol.Exp.Ther. 264 1141 PMID: 8383738
Portoghese et al (1991) Role of spacer and address components in peptidomimetic δ opioid receptor antagonists related to naltrindole. J.Med.Chem. 34 1715 PMID: 1851846
Thorat and Hammond (1997) Modulation of nociception by microinjection of delta-1 and delta-2 opioid receptor ligands in the ventromedial medulla of the rat. J.Pharmacol.Exp.Ther. 283 1185 PMID: 9399992
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Keywords: Naltriben mesylate, Naltriben mesylate supplier, δ2-opioid, delta2-opioid, selective, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0892, Tocris Bioscience
1 Citation for Naltriben mesylate
Citations are publications that use Tocris products. Selected citations for Naltriben mesylate include:
Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Exp Neurobiol 20 RC110 PMID: 11069979
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