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Submit ReviewNBQX
Description: Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Purity: ≥98% (HPLC)
Biological Activity for NBQX
NBQX is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.
NBQX disodium salt, a more water-soluble form of NBQX, also available.
Licensing Information
Sold with the permission of Novo Nordisk A/S
Compound Libraries for NBQX
NBQX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NBQX
| M. Wt | 336.28 |
| Formula | C12H8N4O6S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 118876-58-7 |
| PubChem ID | 3272524 |
| InChI Key | UQNAFPHGVPVTAL-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C1=CC=CC2=C3NC(=O)C(=O)NC3=CC(=C12)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NBQX
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.63 | 100 |
Preparing Stock Solutions for NBQX
The following data is based on the product molecular weight 336.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for NBQX
References for NBQX
References are publications that support the biological activity of the product.
Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814
Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874
Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146 PMID: 7504337
Zeman and Lodge (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781
Yoon et al (2005) Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J.Korean Med.Sci. 20 307 PMID: 15832006
If you know of a relevant reference for NBQX, please let us know.
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Keywords: NBQX, NBQX supplier, Potent, selective, competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, neuroprotective, anticonvulsant, 0373, Tocris Bioscience
180 Citations for NBQX
Citations are publications that use Tocris products. Selected citations for NBQX include:
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Brady et al (2013) Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus. Proc Natl Acad Sci U S A 33 1062 PMID: 23325244
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Gould et al (2008) Involvement of AMPA receptors in the antidepressant-like effects of Li in the mouse tail suspension test and forced swim test. Neuropharmacology 54 577 PMID: 18096191
Kim and Tsien (2008) Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation. Neuron 58 925 PMID: 18579082
Sabater et al (2021) Voltage-gated potassium channels ensure action potential shape fidelity in distal axons. J Neurosci 41 5372 PMID: 34001627
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Kashima and Grueter (2017) Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci U S A. 114 8865 PMID: 28760987
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Lörincz et al (2009) ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks. PLoS One 4 e4447 PMID: 19212445
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Wang et al (2017) Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest 127 1978 PMID: 28414301
Hirono et al (2015) BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. Brain Res 35 7082 PMID: 25948259
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Albright et al (2007) Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice. J Neurophysiol 98 1610 PMID: 17581849
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Partial block of AMPARs.
By
Sergiy Sylantyev on 12/15/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Cerebellar granule cell
NBQX was used to block evoked AMPA-receptor response in outside-out membrane patches excised from hippocampal granule cells. 0.1 µM concentration caused an immediate partial block (see illustration). Highly specific and potent ligand, but requires long sonication to prepare 10 mM DMSO stock.Illustration: I - control AMPAR response at -60 mV cell membrane potential; II - control AMPAR response at +40 mV cell membrane potential; III - NBQX at -60 mV cell membrane potential; IV - NBQX at +40 mV cell membrane potential.
Inhibition of Synaptic Transmission in the VP.
By
Anonymous on 02/02/2020
Assay Type: In Vivo
Species: Mouse
NBQX (5 mM)
an AMPA receptor antagonist.
By
Anonymous on 01/31/2018
Assay Type: Ex Vivo
Species: Rat
It is AMPA receptor antagonist. we used it at 30uM to block AMPA receptor in rat brain slice.
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