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Submit ReviewL-NNA
Description: NOS inhibitor (nNOS = eNOS >> iNOS)
Chemical Name: NG-Nitro-L-arginine
Purity: ≥99% (HPLC)
Biological Activity for L-NNA
NO synthase inhibitor.
Technical Data for L-NNA
| M. Wt | 219.2 |
| Formula | C6H13N5O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 2149-70-4 |
| PubChem ID | 440005 |
| InChI Key | MRAUNPAHJZDYCK-BYPYZUCNSA-N |
| Smiles | N[C@H](C(O)=O)CCCNC(N[N+]([O-])=O)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-NNA
References for L-NNA
References are publications that support the biological activity of the product.
Dwyer et al (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem.Biophys.Res.Commun. 176 1136 PMID: 1710109
Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950
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Keywords: L-NNA, L-NNA supplier, NOS, inhibitors, inhibits, nNOS, eNOS, iNOS, Non-Selective, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Non-selective, 0664, Tocris Bioscience
6 Citations for L-NNA
Citations are publications that use Tocris products. Selected citations for L-NNA include:
Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255 PMID: 23072468
Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. J Neurosci 63 383 PMID: 25327839
Pigott and Garthwaite (2016) Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus. Front Synaptic Neurosci 8 17 PMID: 27445786
Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278 PMID: 20585660
Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400
Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429
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