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Submit ReviewNicergoline
Discontinued Product
0604 has been discontinued.
View all Non-selective Adrenergic α Receptors products.
Description: α antagonist
Chemical Name: (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridine carboxylate ester
Biological Activity for Nicergoline
Nicergoline is a α-adrenergic, vasodilator. Cognitive enhancer.
Technical Data for Nicergoline
| M. Wt | 484.39 |
| Formula | C24H26BrN3O3 |
| Storage | Store at RT |
| CAS Number | 27848-84-6 |
| PubChem ID | 90479736 |
| InChI Key | GCNGMFQQSBSPIJ-XPXYHQFPSA-N |
| Smiles | [H][C@](COC(C5=CN=CC(Br)=C5)=O)1C[C@@](C2=CC=CC3C2C(C4)=CN3C)(OC)[C@]4([H])N(C1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Nicergoline
References for Nicergoline
References are publications that support the biological activity of the product.
Carfagna et al (1995) Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci.Lett. 197 195 PMID: 8552297
Carfagna et al (1996) Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci.Lett. 209 189 PMID: 8736642
Chopin and Briley (1992) Effects of four non-cholinergic cognitive enhancers in comparison with tac. and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 106 26 PMID: 1738791
Merck Index 12 6580
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Keywords: Nicergoline, Nicergoline supplier, α-adrenoceptor, alpha-adrenoceptor, a-adrenoceptor, antagonists, α-adrenergic, alpha-adrenergic, a-adrenergic, Receptors, Non-Selective, vasodilator, Non-selective, Adrenergic, Alpha, 0604, Tocris Bioscience
1 Citation for Nicergoline
Citations are publications that use Tocris products. Selected citations for Nicergoline include:
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.