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[Ala1,3,11,15]-Endothelin

Cat. No. 1197 Submit a Review Datasheet / COA / SDS

Discontinued Product

1197 has been discontinued.

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Description: Selective ETB agonist
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for [Ala1,3,11,15]-Endothelin

[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).

Technical Data for [Ala1,3,11,15]-Endothelin

M. Wt 2368
Formula C109H163N25O32S
Sequence ASASSLMDKEAVYFAHLDIIW
Storage Desiccate at -20°C
CAS Number 121204-87-3
PubChem ID 16143287
InChI Key NRTWVLDGYXCWHD-IGKRDWOESA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for [Ala1,3,11,15]-Endothelin

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for [Ala1,3,11,15]-Endothelin

References are publications that support the biological activity of the product.

Nakamichi et al (1992) Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET1. Biochem.Biophys.Res.Commun. 182 144 PMID: 1310013

Panek et al (1992) Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 183 566 PMID: 1312833

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Keywords: [Ala1,3,11,15]-Endothelin, [Ala1,3,11,15]-Endothelin supplier, Selective, ETB, agonists, Receptors, Endothelin, 1197, Tocris Bioscience

Citations for [Ala1,3,11,15]-Endothelin

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