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Submit ReviewParthenolide
Description: 5-HT release inhibitor
Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Purity: ≥98% (HPLC)
Biological Activity for Parthenolide
The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.
Compound Libraries for Parthenolide
Parthenolide is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for Parthenolide
| M. Wt | 248.32 |
| Formula | C15H20O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 20554-84-1 |
| PubChem ID | 6473881 |
| InChI Key | KTEXNACQROZXEV-SLXBATTESA-N |
| Smiles | C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Parthenolide
References for Parthenolide
References are publications that support the biological activity of the product.
Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553 PMID: 1981582
Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709 PMID: 2877077
Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313 PMID: 1319159
Hehner et al (1998) Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J.Biol.Chem. 273 1288 PMID: 9430659
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Keywords: Parthenolide, Parthenolide supplier, 5-HT, release, inhibitors, inhibits, Serotonin, 5-Hydroxytryptamine, Receptors, 5-HT3, feverfew, 5-HT-Related, NF-kB/IkB, 0610, Tocris Bioscience
2 Citations for Parthenolide
Citations are publications that use Tocris products. Selected citations for Parthenolide include:
Lee et al (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg 7 11322 PMID: 27089465
Schwarz et al (2011) Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of DArgic Neurons in the Ventral Tegmental Area. Curr Neuropharmacol 9 17 PMID: 21886554
Reviews for Parthenolide
Average Rating: 5 (Based on 1 Review.)
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Parthenolide as a behavioral cocaine antagonist.
By
One Pagan on 01/10/2018
Assay Type: In Vivo
Species: Other
Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians
I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.