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Submit ReviewCromakalim
Discontinued Product
1377 has been discontinued.
View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
Description: Kir6 (KATP) channel opener
Alternative Names: BRL 34915
Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Biological Activity for Cromakalim
Cromakalim is a prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM. Potent, orally active and hypotensive in vivo.
Active Enantiomer also available.
Licensing Information
Sold under license
Technical Data for Cromakalim
| M. Wt | 286.33 |
| Formula | C16H18N2O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 94470-67-4 |
| PubChem ID | 76968376 |
| InChI Key | BVMDRSUIADWFLV-PNSAJKJISA-N |
| Smiles | O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3.O=C4CCCN4[C@@H]5[C@@H](O)C(C)(C)OC6=C5C=C(C#N)C=C6 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cromakalim
References for Cromakalim
References are publications that support the biological activity of the product.
Escande et al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620 PMID: 2456760
Longman et al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535 PMID: 2468052
Wilson et al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331 PMID: 2851450
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Keywords: Cromakalim, Cromakalim supplier, KATP, channel, openers, Potassium, KIR, Kir6, Channels, Inward, Rectifier, K+, BRL34915, BRL, 34915, rectifier, 1377, Tocris Bioscience
7 Citations for Cromakalim
Citations are publications that use Tocris products. Selected citations for Cromakalim include:
Mathias and Weid (2013) Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis. Am J Physiol Gastrointest Liver Physiol 304 G623 PMID: 23275612
Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. PLoS One 15 75 PMID: 25886126
Institóris et al (2011) Impaired vascular responses of Ins-resistant rats after mild subarachnoid hemorrhage. PLoS One 300 H2080 PMID: 21421821
Seto et al (2013) Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Heart Circ Physiol 8 e66404 PMID: 23799098
Lasker et al (2013) The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol 304 H1670 PMID: 23585129
Erdos et al (2002) Alterations in KATP and KCa channel function in cerebral arteries of Ins-resistant rats. Am J Physiol Heart Circ Physiol 283 H2472 PMID: 12388242
Whidden et al (2016) Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem 20 58 PMID: 27508155
Reviews for Cromakalim
Average Rating: 5 (Based on 1 Review.)
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Cromakalim used to study BK channel modulation.
By
Sadequl Islam on 11/27/2018
Assay Type: In Vitro
Species: Human
Cromakalim was used to assess the channel opening properties when used on cell line that express BK channels. Gives consistent result that is reproducible.
