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Submit ReviewLevcromakalim
Description: Kir6 (KATP) channel opener; active enantiomer of Cromakalim
Alternative Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥99% (HPLC)
Biological Activity for Levcromakalim
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC50 = 490 nM in guinea pig trachea.
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Sold under license
Technical Data for Levcromakalim
| M. Wt | 286.33 |
| Formula | C16H18N2O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 94535-50-9 |
| PubChem ID | 93504 |
| InChI Key | TVZCRIROJQEVOT-CABCVRRESA-N |
| Smiles | O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Levcromakalim
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.86 | 10 |
Preparing Stock Solutions for Levcromakalim
The following data is based on the product molecular weight 286.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.92 mL | 174.62 mL | 349.25 mL |
| 0.5 mM | 6.98 mL | 34.92 mL | 69.85 mL |
| 1 mM | 3.49 mL | 17.46 mL | 34.92 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.98 mL |
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Product Datasheets for Levcromakalim
References for Levcromakalim
References are publications that support the biological activity of the product.
Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919 PMID: 2002472
Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945 PMID: 1467843
Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429 PMID: 1578358
If you know of a relevant reference for Levcromakalim, please let us know.
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Keywords: Levcromakalim, Levcromakalim supplier, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, BRL38227, BRL, 38227, rectifier, 1378, Tocris Bioscience
3 Citations for Levcromakalim
Citations are publications that use Tocris products. Selected citations for Levcromakalim include:
Fike et al (2013) Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ 3 551 PMID: 24618540
Fransen et al (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip 10 e0121634 PMID: 25803863
Garland et al (2015) TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol 172 1114 PMID: 25323322
Do you know of a great paper that uses Levcromakalim from Tocris? Please let us know.
Reviews for Levcromakalim
Average Rating: 5 (Based on 1 Review.)
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Levcromakalim was used on BK channel opening properties compared to cromakalim.
By
Anonymous on 11/28/2018
Assay Type: In Vitro
Species: Human
Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.
