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Submit ReviewSR 57227 hydrochloride
Description: Potent and selective 5-HT3 agonist
Chemical Name: 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SR 57227 hydrochloride
SR 57227 hydrochloride is a high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant.
Technical Data for SR 57227 hydrochloride
| M. Wt | 248.15 |
| Formula | C10H14ClN3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 77145-61-0 |
| PubChem ID | 131746 |
| InChI Key | FUMINTAAUJUVMP-UHFFFAOYSA-N |
| Smiles | Cl.NC1CCN(CC1)C1=NC(Cl)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SR 57227 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.82 | 100 | |
| DMSO | 24.82 | 100 |
Preparing Stock Solutions for SR 57227 hydrochloride
The following data is based on the product molecular weight 248.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.15 mL | 40.3 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets for SR 57227 hydrochloride
References for SR 57227 hydrochloride
References are publications that support the biological activity of the product.
Bachy et al (1993) SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur.J.Pharmacol. 237 299 PMID: 7689975
Edwards et al (1996) 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 733 21 PMID: 8891244
If you know of a relevant reference for SR 57227 hydrochloride, please let us know.
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1 Citation for SR 57227 hydrochloride
Citations are publications that use Tocris products. Selected citations for SR 57227 hydrochloride include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Dent Res J (Isfahan) 7 2336 PMID: 26114334
Do you know of a great paper that uses SR 57227 hydrochloride from Tocris? Please let us know.
Reviews for SR 57227 hydrochloride
Average Rating: 4 (Based on 1 Review.)
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PGE2 release.
By
jialie luo on 01/10/2018
Assay Type: In Vitro
Species: Mouse
SR 57227 hydrochloride was used to stimulate macrophages as negative control.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.